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<font color="#3333ff"><b><big><big><font face="Calisto MT">PharmFacts
E-News Update -- 29 Sept 2009 AD<br>
</font></big></big></b></font><span
style="font-size: 10pt; font-family: arial;"><font size="3"><font
color="#990000"><strong>This daily e-newsletter is only possible
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<hr size="2" width="100%"><font face="Verdana" size="2"><font
face="Verdana" size="2"><tt><font color="#ff0000"><font
face="Calisto MT, serif"><font face="ARIAL, VERDANA, HELVETICA"><font
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<!--START MAIN HEADLINE--> <img
src="cid:part2.03020407.09040707@pfli.org"><br>
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<a
href="http://www.reuters.com/article/healthNews/idUSTRE58S0D720090929">
<b><i><u><font color="red"><font size="+3">GIRL DIES SHORTLY AFTER
CERVARIX JAB...</font></font></u></i></b></a><b><i><u>
<br>
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<a href="http://www.christiannewswire.com/news/5519911600.html"><b><i><u><font
size="+1">NO UNETHICAL LINES IN 4 NEW H1N1 VACCINES APPROVED...</font></u></i></b></a>
<b><i><u><font size="+1"><br>
<a
href="http://www.mohavedailynews.com/articles/2009/09/29/news/state/state1.txt">
AZ abortoholics challenge patient info and conscience laws; court on
Weds...</a></font></u></i></b></u></i></b></font></font></font></font></tt></font></font><font
color="#3333ff"><big><big><font face="Calisto MT"><small><small><font
color="#000000">
</font></small></small></font></big></big></font>
<p class="MsoNormal"><b><font color="navy" face="Arial" size="3"><span
style="font-size: 12pt; font-family: Arial; color: navy; font-weight: bold;"></span></font></b></p>
<hr size="2" width="100%"><font face="Calisto MT"><b><font color="navy"
size="3"><span
style="font-size: 12pt; font-family: Arial; color: navy; font-weight: bold;">Please
act now on this excellent alert from Eagle Forum. <o:p>
</o:p></span></font></b></font>
<p class="MsoNormal"><font face="Calisto MT"><b><i><font color="navy"
size="3"><span
style="font-size: 12pt; font-family: Arial; color: navy; font-weight: bold; font-style: italic;">Please
note highlighted bullet below regarding abortion
coverage. </span></font></i><font color="navy" size="3"><span
style="font-size: 12pt; font-family: Arial; color: navy; font-weight: bold;"><o:p></o:p></span></font></b></font></p>
<p class="MsoNormal"><font face="Calisto MT"><b><font color="navy"
size="3"><span
style="font-size: 12pt; font-family: Arial; color: navy; font-weight: bold;"><o:p></o:p></span></font></b><strong><b><font
size="3"><span
style="background: yellow none repeat scroll 0% 50%; font-size: 12pt; -moz-background-clip: -moz-initial; -moz-background-origin: -moz-initial; -moz-background-inline-policy: -moz-initial;">Explicitly
provides for abortion funding. </span></font></b></strong><span
style="background: yellow none repeat scroll 0% 50%; -moz-background-clip: -moz-initial; -moz-background-origin: -moz-initial; -moz-background-inline-policy: -moz-initial;">Currently,
the Baucus plan would subsidize plans that cover <i><span
style="font-style: italic;">all elective abortions</span></i>. This
goes far beyond that status quo of current law.<strong><b> </b></strong><b><i><u><font
color="blue"><span
style="color: blue; font-weight: bold; font-style: italic;">Sen. Hatch
is expected to offer an amendment to exclude government-subsidized
abortion funding and protect conscience rights for health care workers</span></font></u></i></b>.
If you recall, the House Democrats approved the Lois Capps (D-CA)
amendment in committee a few weeks ago to officially insert abortion
into H.R. 3200. <strong><b>Calls are
needed to pressure the moderate Democrats and liberal Republican on the
committee in preparation for the Hatch amendment vote on Tuesday</b></strong>: <i><span
style="font-style: italic;">Bingaman (D-MN), Carper (D-DE), Conrad
(D-ND), Lincoln (D-AR), Nelson (D-FL), Snowe (R-ME).<br>
</span></i></span></font></p>
<div>
<p class="MsoNormal"><font face="Calisto MT" size="3"><span
style="font-size: 12pt;"><a
href="http://capwiz.com/eagleforum/utr/1/GKYZLIJSBR/DQFQLIJSOW/4002992046"
target="_blank" title="Seven Fatal Flaws of the Baucus Bill">Seven
Fatal Flaws of the Baucus Bill</a> <o:p></o:p></span></font></p>
</div>
<div> </div>
<font face="Calisto MT" size="3"><span style="font-size: 12pt;"><a
href="http://capwiz.com/eagleforum/utr/1/GKYZLIJSBR/JTBRLIJSOX/4002992046"
target="_blank"
title="Congressman says abortion and STD reporting not required.">Congressman
says abortion and STD reporting not required</a></span></font>
<hr size="2" width="100%"><big><small><strong>A new film</strong>.
There is an important film
currently in post-production that seeks to expose the truth about
abortion. <a href="http://www.bloodmoneyfilm.com/">It is called <em>Blood
Money: The Business of
Abortion</em>.</a> Because of the pro-life nature of the film, the
Producers are trying to rally support to show a major Hollywood
distributor
that there is interest in this country in seeing the film in theaters.
Dr.
Alveda King of our African American outreach, Georgette Forney of our
Silent No More Awareness Campaign, and I were privileged to participate
on
camera.</small><br>
<br>
</big><font color="#3333ff"><big><big><font face="Calisto MT"><small><small><font
color="#000000"></font></small></small></font></big></big></font>
<hr size="2" width="100%"><img
src="cid:part4.01010609.09090008@pfli.org" alt="" height="174"
width="269">
<p><b>More Mockery: Judge in Case of Arrested Notre Dame
Pro-Lifers is Married to Pro-Abortion ND Professor</b><a name="3"></a><br>
<br>
</p>
<p><small>By Kathleen Gilbert</small></p>
<p><small>SOUTH BEND,
Indiana, September 28, 2009 (<a href="http://www.lifesitenews.com/">LifeSiteNews.com</a>)
- The attorney
representing the pro-lifers arrested while protesting Obama at Notre
Dame today repeated his request that the judge in the case, who is
married to a pro-abortion Notre Dame professor, be removed from the
case.</small></p>
<p><small>Attorney Tom Dixon's motion provides detailed support
for his assertion in a previous recusal motion that there exists
sufficient actual and perceived bias that Judge Jenny Pitts Manier, the
judge assigned to the "ND 88" case, is required by Indiana
state law to recuse herself in the matter. Dixon states that ever
since Judge Manier has known her husband, Professor Edward Manier, he
has been a well-known and outspoken advocate of the pro-abortion
position.</small></p>
<p><small>As his views were well-known and have largely defined
his identity at Notre Dame, Dixon argues, it seems implausible that
Judge Manier could claim to be unaware of his views on the "ND
88" case, which stem from "the single biggest controversy in
the history of the University of Notre Dame."</small></p>
<p><small>The case
surrounds the arrest of 88 pro-lifers from across America who were
charged with trespassing after peacefully witnessing against the
presence of President Obama at Notre Dame The university awarded Obama
with the commencement speech and an honorary law degree on May 17 of
this year. Arrestees were singled out for carrying pro-life
messages onto campus - including images of aborted children, a large
cross, and images of Mary - while several other trespassers with
pro-Obama or pro-Notre Dame signage were allowed to roam the
campus.</small></p>
<p><small>Dixon argues that the career of Judge Manier's husband
at Notre Dame was largely defined by the very same controversies which
prompted the pro-lifers to travel across America to ultimately land in
the St. Joseph County court room. In Indiana, a judge must recuse
himself or herself from a case in the event of actual or perceived
bias.
</small></p>
<p><small>In the original recusal motion in August, Dixon says that
Judge
Manier refused to answer whether her husband had ever written on the
topic of abortion, saying only, "I'm not my
husband." </small></p>
<p><small>Dixon highlights several ways in which
actual and perceived bias exists in the "ND 88" case. In
addition to several writings revealing his pro-abortion beliefs, the
professor donated "a significant sum of money" to Barack
Obama's 2008 Presidential campaign, as well as additional donations
to other pro-abortion rights candidates in the United States.
</small></p>
<p><small>Manier, a supporter of the production of "The Vagina
Monologues" on Notre Dame's campus, also attacked
Pope Paul Paul VI's pro-life encyclical Humanae Vitae as
"intellectually stillborn."</small></p>
<p><small>"When one analyzes
Edward Manier's political contributions to pro abortion candidates
and Political Action Committee, when one reads Edward Manier's
writings referencing members of the Christian right, calling them
'fundamentalist mullahs' and 'jackleg preachers,'"
Dixon writes, "it is hard to comprehend how Judge Manier could
derive from her husband's writings the notion that he has no
interest in the outcome of these cases."</small></p>
<p><small>Last week,
University of Notre Dame law professor emeritus Charles Rice <a
href="http://www.lifesitenews.com/ldn/2009/sep/09092405.html">issued</a>
an open letter to University president Fr. John Jenkins, saying that
the
school's attempts at reconstructing a pro-life image were a
"mockery" while yet refusing to request leniency for the 88
pro-lifers awaiting trial. </small></p>
<p><small><br>
See related LifeSiteNews.com coverage:</small></p>
<p><small><a
href="http://www.lifesitenews.com/ldn/2009/sep/09092405.html">Notre
Dame
Pro-Life Efforts a "Mockery" While Pro-Life Protesters
Continue to Face Charges: ND Law Prof</a> </small></p>
<p><small><a
href="http://www.lifesitenews.com/ldn/2009/sep/09090405.html">88
Pro-Lifers Arrested at Notre Dame Still Facing Jail Time: Thomas More
Lawyer Again Asks Fr. Jenkins for Leniency</a> </small></p>
<p><small><a
href="http://www.lifesitenews.com/ldn/2009/jun/09061007.html">ND Prez
Jenkins Has "No Interest" in Asking for Leniency for ND
Protesters Despite Calls for "Dialogue"</a> </small></p>
<small><a
href="mailbox:///C%7C/Program%20Files/Mozilla%20Thunderbird/defaults/profile/bo/Mail/Local%20Folders/Inbox?number=4703737#0"></a><a
href="http://www.lifesite.net/ldn/printerfriendly.html?articleid=09092808">Print
this Story</a> | <a
href="http://www.lifesite.net/ldn/sendtofriend.html?articleid=09092808">Email
to a Friend</a> | <a
href="http://www.lifesite.net/ldn/viewonsite.html?articleid=09092808">View
Story on LifeSiteNews.com</a><br>
</small>
<hr size="2" width="100%"><small><br>
</small>
<div><big><font id="role_document" color="#000000" face="Calisto MT"
size="2"><big><b>From the files of Dr Dianne Irving .....</b><br>
<br>
FYI -- short list of references from studies recently published in
PubMed concerning the endorsement and use of cloning by "embryo
splitting" as "infertility treatments, and the push by lawyers to
change and deconstruct the critical and accurate scientific terms of
human embryology in law for "new practices and new times". With these
new fabricated "scientific" terms, the public won't even be able to
tell what kinds of human embryo research, human cloning, human genetic
engineering, or "infertility treatments" they are doing any more.
Please pass on to interested others. <strong>The term "abortion" no
longer involves only sexually reproduced human embryos, and the term
"cloning" no longer involves only the SCNT cloning technique.</strong></big></font></big></div>
<div><big><font id="role_document" color="#000000" face="Calisto MT"
size="2"><big> </big></font></big></div>
<div><big><font id="role_document" color="#000000" face="Calisto MT"
size="2"><big>In fact, neither have been true for some time now. -- DNI</big></font></big></div>
<div><font id="role_document" color="#000000" face="Arial" size="2"> <br>
</font></div>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><font
id="role_document" color="#000000" face="Arial" size="2"><b style=""><span
style="font-size: 14pt;"><font face="Times New Roman">--<span style="">
</span>“Embryo-splitting” endorsed for “infertility treatments:<o:p></o:p></font></span></b></font></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">The <b
style="">American Medical Association</b> has recently renewed its
position on the use of "embryo splitting" (i.e., a form of cloning) as
infertility treatments. FYI, I have copied the URL for this latest
report, as well as the URL provided there for the original 1994 report
which has been serially updated. -- DNI<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <i
style="">Code of Medical Ethics</i> (Sept 21, 2009)<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><font
id="role_document" color="#000000" face="Arial" size="2"><font
face="Times New Roman"><b style=""><span
style="color: black; font-size: 14pt;">Opinion 2.145 - Pre-embryo
Splitting (a summary)</span></b><span style="color: black;"><font
size="3"> [[note the use of the erroneous scientific term
“pre-embryo”]]<o:p></o:p></font></span></font></font></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"><a class="moz-txt-link-freetext" href="http://www.ama-assn.org/ama/pub/physician-resources/medical-ethics/code-medical-ethics/opinion2145.shtml">http://www.ama-assn.org/ama/pub/physician-resources/medical-ethics/code-medical-ethics/opinion2145.shtml</a><o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">This
Report provides a hyperlink to the original 1994 report that explains
“blastomere separation” and “blastocyst splitting” in IVF facilities
for “infertility treatments”:<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><font
id="role_document" color="#000000" face="Arial" size="2"><b style=""><span
style=""><font size="3"><font face="Times New Roman">CEJA Report 1-I-94<o:p></o:p></font></font></span></b></font></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">Recent
medical developments have enabled scientific researchers to split human
pre-embryos into genetically identical sibling embryos.<span style="">
</span>...<span style=""> </span>The first two techdniques involve
the procedure of “splitting” or “twinning” embryos.<span style=""> </span>“Blastomere
separation” involves the division of a four-cell or eight-cell
pre-embryo into the individual totipotent cells (blastomeres), or
groups of such cells, which comprise it.<span style=""> </span>...
The splitting of blastocysts ... is referred to as “embryo splitting”.<span
style=""> </span>In this technique, a blastocyst is bisected into
two multicellular groups of non-totipotent cells, each of which is
nurtured to encourage further development.<span style=""> </span>...<span
style=""> </span>The technique of splitting in vitro fertilized
pre-embryos may result in multiple genetically identical siblings.<span
style=""> </span>The procedure of pre-embryo splitting should be
available so long as both gamete providers agree.<span style=""> </span>This
procedure may significantly increase the chances of conception for an
infertile couple or for a couple whose future reproductive capacity
will likely be diminished.<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">American
Medical Association<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">“Section
61.<span style=""> </span>Pre-embryo Splitting”<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">Dec,
1994<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"><a class="moz-txt-link-freetext" href="http://www.ama-assn.org/ama/upload/mm/369/ceja_report_061.pdf">http://www.ama-assn.org/ama/upload/mm/369/ceja_report_061.pdf</a><o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">*********************************************************************<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><o:p><font id="role_document" color="#000000"
face="Arial" size="2"><font face="Times New Roman" size="3"> </font></font></o:p></span><font
id="role_document" color="#000000" face="Arial" size="2"><font
face="Times New Roman"><b><span style="color: black; font-size: 14pt;">--
Twinning for "infertility treatments"</span></b><span
style="color: black; font-size: 14pt;"><o:p></o:p></span></font></font></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><font
id="role_document" color="#000000" face="Arial" size="2"><font size="3"><font
face="Times New Roman"><b><span style="color: black;">Human embryo
twinning with applications in reproductive medicine</span></b><span
style="color: black;"><o:p></o:p></span></font></font></font></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Illmensee K"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Illmensee%20K%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span
style="color: rgb(90, 89, 123);"><font face="Times New Roman" size="3">Illmensee
K</font></span></a><font face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Levanduski M"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Levanduski%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span
style="color: rgb(90, 89, 123);"><font face="Times New Roman" size="3">Levanduski
M</font></span></a><font face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Vidali A"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Vidali%20A%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span
style="color: rgb(90, 89, 123);"><font face="Times New Roman" size="3">Vidali
A</font></span></a><font face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Husami N"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Husami%20N%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span
style="color: rgb(90, 89, 123);"><font face="Times New Roman" size="3">Husami
N</font></span></a><font face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Goudas VT"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Goudas%20VT%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><span
style="color: rgb(90, 89, 123);"><font face="Times New Roman" size="3">Goudas
VT</font></span></a><o:p></o:p></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">OBJECTIVE:
To assess the efficacy of human embryo twinning by blastomere biopsy at
different early embryonic stages (splitting efficiency) and to
determine the in vitro developmental capacity of twinned human embryos
(developmental efficiency). DESIGN: Randomized comparative study.
SETTING: Private IVF centers. PATIENT(S): Couples undergoing IVF
donating triploid embryos. INTERVENTION(S): Embryos at the 2- to 5- and
6- to 8-cell stage were split into twin embryos. Half the number of
blastomeres from donor embryos were removed and inserted into recipient
empty zonae pellucidae. After embryo splitting, donor and recipient
embryos were cultured in vitro. MAIN OUTCOME MEASURE(S): Development of
twinned embryos to the blastocyst stage. RESULT(S): The number of
developing embryos obtained after splitting could be increased in
comparison with the number of embryos available before splitting at the
6- to 8-cell stage but not at the 2- to 5-cell stage (splitting
efficiency). Splitting of 6- to 8-cell embryos yielded superior rates
of twin embryos developing to blastocysts (developmental efficiency).
Twinning success was related to the superior morphological quality of
embryos used for splitting. CONCLUSION(S): This is the first report on
twinned human embryos developing to blastocysts. This study exhibits
the potential for novel applications in human assisted reproduction.<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">PMID:
19217091;<span style=""> </span></font></font><a
title="javascript:AL_get(this, 'jour', 'Fertil Steril.');"
href="javascript:AL_get(this,%20'jour',%20'Fertil%20Steril.');"><span
style="color: rgb(90, 89, 123);"><font face="Times New Roman" size="3">Fertil
Steril.</font></span></a><font size="3"><font face="Times New Roman">
2009 Feb 11.<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"><a class="moz-txt-link-freetext" href="http://www.ncbi.nlm.nih.gov/pubmed/19217091?ordinalpos=52&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">http://www.ncbi.nlm.nih.gov/pubmed/19217091?ordinalpos=52&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum</a><o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">***********************************************************<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> </font></font></font></span><font
id="role_document" color="#000000" face="Arial" size="2"><font
face="Times New Roman"><b><span style="color: black; font-size: 14pt;">--
Proving some cells of the early human embryo are totipotent, form new
embryos</span></b><span style="color: black; font-size: 14pt;"><o:p></o:p></span></font></font></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Van de Velde H"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Van%20de%20Velde%20H%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Van de
Velde H</font></span></b></a><font face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Cauffman G"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Cauffman%20G%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Cauffman G</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Tournaye H"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tournaye%20H%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Tournaye H</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Devroey P"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Devroey%20P%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Devroey P</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Liebaers I"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Liebaers%20I%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Liebaers I</font></span></b></a><o:p></o:p></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><font
id="role_document" color="#000000" face="Arial" size="2"><font size="3"><font
face="Times New Roman"><b><span style="color: black;">The four
blastomeres of a 4-cell stage human embryo are able to develop
individually into blastocysts with inner cell mass and trophectoderm</span></b><span
style="color: black;"><o:p></o:p></span></font></font></font></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">Research
Centre Reproduction and Genetics, Universitair Ziekenhuis Brussel (UZ
Brussel), Laarbeeklaan 101, 1090 Brussels, Belgium.
<a class="moz-txt-link-abbreviated" href="mailto:hilde.vandevelde@uzbrussel.be">hilde.vandevelde@uzbrussel.be</a><o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">BACKGROUND:
Early mammalian blastomeres are thought to be flexible and totipotent
allowing the embryo to overcome perturbations in its organization
during preimplantation development. In the past, experiments using
single blastomeres from 2-, 4- and 8-cell stage mammalian embryos have
provided evidence that at least some of the isolated cells can develop
into healthy fertile animals and therefore are totipotent. We
investigated whether isolated blastomeres of human 4-cell stage embryos
could develop in vitro into blastocysts with trophectoderm (TE) and
inner cell mass (ICM). METHODS: Six 4-cell stage human embryos were
split and the four blastomeres were cultured individually. The
expression of NANOG, a marker for ICM cells, was analysed by
immunocytochemistry. RESULTS: The majority of the blastomere-derived
embryos followed the normal pattern of development with compaction on
Day 4 and cavitation on Day 5 and developed into small blastocysts with
TE and ICM on Day 6 (n = 12). The four cells of one embryo were
individually capable of developing into blastocysts with TE and ICM,
and NANOG was expressed in the ICM. CONCLUSIONS: Although based on a
small number of embryos, we conclude that the blastomeres of a 4-cell
stage human embryo are flexible and able to develop into blastocysts
with ICM and TE.<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">PMID:
18503052 <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><a
title="javascript:AL_get(this, 'jour', 'Hum Reprod.');"
href="javascript:AL_get(this,%20'jour',%20'Hum%20Reprod.');"><span
style="color: blue;"><font face="Times New Roman" size="3">Hum Reprod.</font></span></a><font
size="3"><font face="Times New Roman"> 2008 Aug;23(8):1742-7. Epub
2008 May 24<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><a
title="http://www.ncbi.nlm.nih.gov/pubmed/18503052?ordinalpos=107&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum"
href="http://www.ncbi.nlm.nih.gov/pubmed/18503052?ordinalpos=107&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum"><span
style="color: blue;"><font face="Times New Roman" size="3">http://www.ncbi.nlm.nih.gov/pubmed/18503052?ordinalpos=107&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum</font></span></a><o:p></o:p></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">******************************************************************<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><font
id="role_document" color="#000000" face="Arial" size="2"><font
face="Times New Roman"><b><span style="color: black; font-size: 14pt;">--
Proving mix of totipotency and pluripotency in cells of early human
embryo</span></b><span style="color: black; font-size: 14pt;"><o:p></o:p></span></font></font></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><a
title="http://www.ncbi.nlm.nih.gov/pubmed/19633307?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum"
href="http://www.ncbi.nlm.nih.gov/pubmed/19633307?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum"><span
style="color: blue;"><font face="Times New Roman" size="3">http://www.ncbi.nlm.nih.gov/pubmed/19633307?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum</font></span></a><o:p></o:p></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><font
id="role_document" color="#000000" face="Arial" size="2"><b><span
style="color: black;"><font size="3"><font face="Times New Roman">Human
embryonic stem cell lines derived from single blastomeres of two 4-cell
stage embryos.<o:p></o:p></font></font></span></b></font></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Geens M"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Geens%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Geens M</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Mateizel I"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Mateizel%20I%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Mateizel I</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Sermon K"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Sermon%20K%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Sermon K</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="De Rycke M"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22De%20Rycke%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">De Rycke M</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Spits C"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Spits%20C%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Spits C</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Cauffman G"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Cauffman%20G%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Cauffman G</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Devroey P"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Devroey%20P%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Devroey P</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Tournaye H"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tournaye%20H%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Tournaye H</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Liebaers I"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Liebaers%20I%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Liebaers I</font></span></b></a><font
face="Times New Roman" size="3">, </font><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Van de Velde H"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Van%20de%20Velde%20H%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">Van de
Velde H</font></span></b></a><font size="3"><font face="Times New Roman">.<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">Department
of Embryology and Genetics (EMGE), Vrije Universiteit Brussel (VUB),
Laarbeeklaan 101, 1090 Brussels, Belgium.<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><font
id="role_document" color="#000000" face="Arial" size="2"><font size="3"><font
face="Times New Roman"><span style="color: black;">BACKGROUND
Recently, we demonstrated that </span><b><span style="">single
blastomeres of a 4-cell stage human embryo are able to develop into
blastocysts with inner cell mass and trophectoderm.</span></b><span
style=""> To further investigate potency at the 4-cell stage, we aimed
to derive pluripotent human embryonic stem cells (hESC) from single
blastomeres. METHODS Four 4-cell stage embryos were split on Day 2 of
preimplantation development and the 16 blastomeres were individually
cultured in sequential medium. On Day 3 or 4, <b>the
blastomere-derived embryos</b> were plated on inactivated mouse
embryonic fibroblasts (MEFs). RESULTS Ten out of sixteen
blastomere-derived morulae attached to the MEFs, and two produced an
outgrowth. They were mechanically passaged onto fresh MEFs as described
for blastocyst ICM-derived hESC, and shown to express the typical
stemness markers by immunocytochemistry and/or RT-PCR. In vivo
pluripotency was confirmed by the presence of all three germ layers in
the teratoma obtained after injection in immunodeficient mice. The
first hESC line displays a mosaic normal/abnormal 46, XX,
dup(7)(q33qter), del(18)(q23qter) karyotype. The second hESC line
displays a normal 46, XY karyotype. CONCLUSION We report the successful
derivation and characterization of two hESC lines from single
blastomeres of four split 4-cell stage human embryos. These two hESC
lines were <b>derived from distinct embryos, proving that at least one
of the 4-cell stage blastomeres is pluripotent.</b><o:p></o:p></span></font></font></font></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><a
title="javascript:AL_get(this, 'jour', 'Hum Reprod.');"
href="javascript:AL_get(this,%20'jour',%20'Hum%20Reprod.');"><span
style="color: blue;"><font face="Times New Roman" size="3">Hum Reprod.</font></span></a><font
size="3"><font face="Times New Roman"> 2009 Jul 24. [Epub ahead of
print]<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">PMID:
19633307 [PubMed - as supplied by publisher]<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">************************************************************<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><font
id="role_document" color="#000000" face="Arial" size="2"><font
face="Times New Roman"><b><span style="color: black; font-size: 14pt;">--
Human embryo in law should be defined as just a "group of cells"</span></b><span
style="color: black; font-size: 14pt;"><o:p></o:p></span></font></font></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><a
title="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="de Miguel Beriain I"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"
href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22de%20Miguel%20Beriain%20I%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"><b><span
style="color: blue;"><font face="Times New Roman" size="3">de Miguel
Beriain I</font></span></b></a><o:p></o:p></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">Cátedra
Interuniversitaria Fundación BBVA, Diputación Foral de Bizkaia de
Derecho y Genoma Humano, Universidad de Deusto-Universidad del País
Vasco, Bilbao, España.<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><font
id="role_document" color="#000000" face="Arial" size="2"><font size="3"><font
face="Times New Roman"><b><span style="color: black;">The human embryo
after Dolly: new practices for new times</span></b><span
style="color: black;"><o:p></o:p></span></font></font></font></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">The
possiblity of cloning human beings introduced a lot of issues in our
ethical and legal frameworks. In this paper, we will put the focus into
the necessary changes in the concept of embryo that our legal systems
will have to implement in order to face the new situation. The
description of the embryo as a group of cells able to develop into a
human being will be defended here as the best way of doing so.<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 10pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">PMID:
19334406 <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><a
title="http://www.ncbi.nlm.nih.gov/pubmed/19334406?ordinalpos=112&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum"
href="http://www.ncbi.nlm.nih.gov/pubmed/19334406?ordinalpos=112&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum"><span
style="color: blue;"><font face="Times New Roman" size="3">http://www.ncbi.nlm.nih.gov/pubmed/19334406?ordinalpos=112&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum</font></span></a><o:p></o:p></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><o:p><font id="role_document" color="#000000"
face="Arial" size="2"><font face="Times New Roman" size="3"> </font></font></o:p></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">*****************************************************************<o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> </font></font></font></span><font
id="role_document" color="#000000" face="Arial" size="2"><font
face="Times New Roman"><b><span style="color: black; font-size: 14pt;">--
Need for legally redefining everything about the "human embryo"</span></b><span
style="color: black; font-size: 14pt;"><o:p></o:p></span></font></font></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman">Amazing
law article that attempts to redefine the human embryo. Unreal. <o:p></o:p></font></font></font></span></p>
<p style="margin: 0in 0in 0pt;" class="MsoNormal"><span
style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><font size="3"><font face="Times New Roman"> <o:p></o:p></font></font></font></span></p>
<span style="color: black;"><font id="role_document" color="#000000"
face="Arial" size="2"><a
title="http://www.bedfordresearch.org/newsandlibrary/files/CLRPub04.pdf"
href="http://www.bedfordresearch.org/newsandlibrary/files/CLRPub04.pdf"><span
style="color: blue;"><font face="Times New Roman" size="3">http://www.bedfordresearch.org/newsandlibrary/files/CLRPub04.pdf</font></span></a></font></span><font
color="#3333ff"><big><big><font face="Calisto MT"><small><small><font
color="#000000">
</font></small></small></font></big></big></font>
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