[Pflienews] PharmFacts E-News Update: OCs use and Breast Cancer Incidence

[PFLI PharmAid Center]

*PharmFacts E-News Update -- 13 Jan 2009 AD

*Not really news, but once again confirms what PFLI has reported for 
decades: OCs are abortifacient and dangerous to both the mom users and 
the preborn babies.
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http://aje.oxfordjournals.org/cgi/content/short/kwn360v1


    A Case-Control Study of Oral Contraceptive Use and Incident Breast
    Cancer

* Lynn Rosenberg, Yuqing Zhang, Patricia F. Coogan, Brian L. Strom and 
Julie R. Palmer *

Correspondence to Dr. Lynn Rosenberg, Slone Epidemiology Center at 
Boston University, 1010 Commonwealth Avenue, Boston, MA 02215 (e-mail: 
lrosenberg at slone.bu.edu <mailto:lrosenberg at slone.bu.edu> ).

/Received for publication July 1, 2008./ /Accepted for publication 
October 10, 2008./

Oral contraceptive (OC) use has been linked to increased risk^ of breast 
cancer, largely on the basis of studies conducted^ before 1990. In the 
Case-Control Surveillance Study, a US hospital-based^ case-control study 
of medication use and cancer, the authors^ assessed the relation of OC 
use to breast cancer risk among^ 907 case women with incident invasive 
breast cancer (731 white,^ 176 black) and 1,711 controls (1,152 white, 
559 black) interviewed^ from 1993 to 2007. They evaluated whether the 
association differed^ by ethnicity or tumor hormone receptor status. 
After control^ for breast cancer risk factors, the multivariable odds 
ratio^ for 1 year or more of OC use, relative to less than 1 year of^ 
use, was 1.5 (95% confidence interval: 1.2, 1.8). The estimates^ were 
similar within age strata (<50 years and ?50 years).^ The odds ratios 
were larger for use within the previous 10 years,^ long-duration use, 
and black ethnicity, but these differences^ were not statistically 
significant. The association of OC use^ with breast cancer risk did not 
differ according to the estrogen^ or progestogen receptor status of the 
tumor. These results suggest^ that OC use is associated with an 
increased risk of breast cancer^ diagnosed in recent years.^

breast neoplasms; case-control studies; contraceptives, oral

Abbreviations: CARE, Contraceptive and Reproductive Experiences; CI, 
confidence interval; ER, estrogen receptor; OC(s), oral 
contraceptive(s); PR, progestogen receptor


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